Growth Hormone Support
CJC-1295
A GHRH analogue that amplifies your own growth hormone release for body composition, recovery, and anti-aging. Most often paired with ipamorelin for a synergistic GH pulse. Physician-prescribed and pharmacy-compounded for California patients.
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Physician-reviewed peptide therapy, prescribed only when appropriate.
Protocol at a glance
- Dose
- 100–200 mcg
- Route
- Subcutaneous injection
- Frequency
- Daily (without DAC)
- Course
- 3–6 months to assess
- Typical cost
- $100–200/mo
Physician-reviewed. Prescribed only if appropriate after a telehealth consult — full refund if a licensed clinician determines it isn't right for you.
Why patients choose it
Why patients choose CJC-1295
Amplifies your own GH
A more stable GHRH analogue that boosts both GH secretion and downstream IGF-1 — without injecting synthetic HGH.
Stacks with ipamorelin
Works through a different pathway than ipamorelin, so combined they produce a GH pulse larger than either alone.
Feedback stays intact
Your somatostatin feedback loop keeps regulating output, which supports a favorable profile for long-term, supervised use.
Overview
What CJC-1295 is
CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) — the hypothalamic signal that tells the pituitary to release growth hormone. It was developed to have greater stability and a longer half-life than natural GHRH, which has a half-life of only a few minutes. By amplifying the GHRH signal, CJC-1295 increases both GH secretion and downstream IGF-1 production.
It is available in two forms: with DAC (extended half-life, weekly dosing) and without DAC (Mod GRF 1-29, daily dosing for pulsatile GH release). Most prescribing physicians prefer the without-DAC version for a more physiologic GH pattern — short half-life (~30 minutes), often combined with ipamorelin in the same injection.
Candidacy
Who it's for
CJC-1295 is most often pursued by adults over 30 experiencing age-related GH decline who want a natural optimization approach rather than synthetic HGH. California patients who ask about it typically fall into one of these groups:
- Fitness-focused individuals pursuing body recomposition — lean mass gain, fat loss
- Athletes focused on improving exercise recovery and reducing injury risk
- Patients on a comprehensive anti-aging protocol alongside sermorelin, ipamorelin, or GHK-Cu
- Those who want GH support without the cost or risks of synthetic HGH injections
What to expect
How it unfolds, week by week
01
Weeks 1–4
Improved sleep quality is usually the first change, with occasional mild water retention as GH levels increase.
02
Weeks 4–8
Enhanced exercise recovery, increased energy, and subtle improvements in skin tone are reported in this window.
03
Weeks 8–16
Visible body composition changes emerge with consistent training, alongside improved strength.
04
Months 4–6+
Meaningful lean mass development, sustained fat reduction, and bone density improvements. IGF-1 is typically monitored to keep levels in a healthy range.
CJC-1295 without DAC vs. with DAC
| Without DAC (Mod GRF 1-29) | With DAC | |
|---|---|---|
| Half-life | Short (~30 min) — produces pulsatile GH release mimicking natural physiology. | Extended (6–8 days) via albumin binding — produces sustained GH elevation rather than pulses. |
| Dosing | 100–200 mcg daily, often combined with ipamorelin in the same injection. | Dosed 1–2x per week — more convenient. |
| Considerations | Preferred by most prescribing physicians for long-term protocols. | May cause more pronounced water retention and joint stiffness in some patients. |
Safety
Side effects & long-term use
Based on current clinical experience, CJC-1295 (without DAC) has a favorable safety profile for long-term use under physician supervision. Because it stimulates natural GH production rather than introducing exogenous HGH, the feedback regulation mechanism remains intact — the body can regulate output. Potential effects to watch for:
- Water retention, particularly when starting
- Joint stiffness
- Elevated IGF-1 if doses are excessive
Regular monitoring of IGF-1 minimizes these risks and keeps levels within a healthy physiologic range.
Pricing
Cost in California
Compounded CJC-1295 runs $100–200/month as a standalone. When combined with ipamorelin in a single vial — the most common protocol — the combined cost is typically $200–350/month. Physician consultation is $99–199 initially. See our full cost guide.
FAQ
CJC-1295 questions
Related peptides
Often explored together
Ipamorelin
Selective GH secretagogue — the standard partner stacked with CJC-1295.
Learn more →Sermorelin
GHRH analogue with a shorter half-life, often the entry point to GH peptides.
Learn more →Tesamorelin
GHRH analogue studied for visceral fat reduction.
Learn more →MK-677
Oral GH secretagogue — no injection required.
Learn more →Get CJC-1295 in California
Physician consultation, prescription, and pharmacy delivery. No clinic visit required.
Check Your EligibilityCJC-1295
Physician-reviewed