Glutathione

Glutathione is a tripeptide — glutamine, cysteine, and glycine — produced in every cell of the body. It is often called the "master antioxidant" because it directly neutralizes free radicals, regenerates other antioxidants like vitamins C and E, and is the primary molecule the liver uses for phase II detoxification.

Glutathione synthesis declines with age — levels drop roughly 1% per year after age 45. But age is not the only drain: chronic stress, alcohol use, heavy metal exposure, pharmaceutical medications (especially acetaminophen and statins), chronic illness, and intense exercise all deplete glutathione faster than the body can produce it. When it is depleted, phase II detoxification slows, free radicals accumulate, mitochondrial function declines, and immune response weakens.

Glutathione is delivered parenterally because oral forms are largely broken down in the GI tract before reaching the bloodstream. The main options:

• IV infusion: Highest bioavailability and fastest effect — 400–1200 mg over 20–60 minutes per session.
• Intramuscular injection: Convenient for home use — commonly 600–1200 mg per session, 2–3x weekly.
• Inhalation (nebulized): Used for certain lung conditions.
• Sublingual or liposomal oral: Lower bioavailability but still higher than standard oral glutathione.

Injectable glutathione for home use (IM) runs $100–250/month. IV sessions at clinics run $150–400 per infusion. Consultation fees are $99–199. See our full cost guide.