Growth Hormone Support
Ipamorelin
A selective growth hormone secretagogue for anti-aging, lean body composition, deeper sleep, and energy — a clean GHRP that prompts your own pituitary to release GH without spiking cortisol or appetite. Physician-prescribed and pharmacy-compounded for California patients.
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Physician-reviewed peptide therapy, prescribed only when appropriate.
Protocol at a glance
- Dose
- 200–300 mcg
- Route
- Subcutaneous injection
- Frequency
- Once daily
- Timing
- Before bed, fasted
- Course
- 8–16 weeks to assess
- Typical cost
- $150–300/mo
Physician-reviewed. Prescribed only if appropriate after a telehealth consult — full refund if a licensed clinician determines it isn't right for you.
Why patients choose it
Why patients choose ipamorelin
Clean and selective
One of the most selective GHRPs available — a strong GH pulse without meaningfully raising cortisol, prolactin, or appetite hormones.
Sleep comes first
Deeper, more restorative sleep is usually the earliest change — often within the first 2–4 weeks of starting.
Built to stack
Pairs synergistically with CJC-1295 or sermorelin, producing significantly amplified GH pulses than either peptide alone.
Overview
What ipamorelin is
Ipamorelin is a synthetic pentapeptide and growth hormone-releasing peptide (GHRP) that stimulates the pituitary gland to secrete growth hormone. It is considered one of the cleanest and most selective GHRPs available — it produces a strong GH pulse without meaningfully elevating cortisol, prolactin, or appetite hormones, side effects that limited the use of earlier GHRPs like GHRP-2 and GHRP-6.
Ipamorelin binds to the ghrelin receptor (GHS-R1a) on pituitary somatotrophs, triggering a pulsatile release of growth hormone that mimics the body's natural secretion pattern and preserves feedback regulation. Its short half-life — roughly 2 hours — means consistent effect requires daily injection. When stacked with a GHRH analogue like CJC-1295 or sermorelin, the two mechanisms work together to produce significantly amplified GH pulses.
Most detailed mechanism research is from animal studies. Human data is primarily from clinical experience. Consult your physician for treatment decisions.
Candidacy
Who it's for
California patients who commonly pursue ipamorelin therapy include adults over 35 experiencing the declining GH production that typically begins in the 30s. It appeals to those seeking body-composition improvement without the risks of synthetic HGH.
Patients who ask about ipamorelin typically describe some combination of:
- Declining GH production with age, starting in the 30s
- A desire for lean body composition without the risks of synthetic HGH
- Poor sleep quality, low energy, or reduced exercise recovery
- Interest in a natural alternative to HRT or testosterone therapy for anti-aging
- A body-recomposition goal — building lean mass while reducing fat
What to expect
How it unfolds, week by week
01
Weeks 1–4
Improved sleep depth and quality; some patients report vivid dreams as GH pulses during sleep normalize.
02
Weeks 4–8
Increased energy, improved workout recovery, and subtle mood improvements are reported in this window.
03
Weeks 8–16
Visible body composition changes become apparent — reduced body fat and increased lean muscle mass.
04
Months 4–6+
Skin quality improvements, improved bone density markers, and sustained energy gains develop over the longer term.
Ipamorelin vs. Sermorelin
| Ipamorelin | Sermorelin | |
|---|---|---|
| Class | GHRP — a growth hormone-releasing peptide. | GHRH analogue — mimics natural growth hormone-releasing hormone. |
| Mechanism | Acts on the ghrelin receptor (GHS-R1a) on pituitary somatotrophs. | Signals the pituitary through the GHRH receptor. |
| Stacking | Frequently paired with CJC-1295 (without DAC) for a synergistic, stronger GH pulse. | Often the starting point; complementary to a GHRP like ipamorelin. |
| Typical cost | $150–300/month | $200–350/month |
Protocol
Administration
A standard protocol is 200–300mcg by subcutaneous injection, once daily before bed. Timing matters — ipamorelin works best when GH release is not blunted by elevated blood sugar, so dosing fasted or after a 2-hour fast from carbohydrates is recommended.
The most popular protocol pairs ipamorelin (GHRP) with CJC-1295 without DAC (GHRH analogue). The two mechanisms work synergistically, producing a larger GH pulse than either alone, and are often prescribed as a combined injection. Your physician will tailor the protocol to your goals and baseline labs.
Safety
Side effects & contraindications
Ipamorelin is generally well-tolerated. Side effects are usually mild:
- Occasional injection site discomfort
- Mild water retention in the first few weeks
- Rare headache
No significant cortisol elevation has been documented with ipamorelin, unlike some older GHRPs. Discuss your full health history with your prescribing physician before starting.
Pricing
Cost in California
Compounded ipamorelin runs $150–300/month depending on dose and whether it is combined with CJC-1295 in the same vial (combination vials are more cost-efficient). Initial physician consultation is typically $99–199. See our full cost guide for current pricing.
FAQ
Ipamorelin questions
Related peptides
Often explored together
Sermorelin
GHRH analogue and common starting point for GH peptide therapy.
Learn more →CJC-1295
Long-acting GHRH analogue; the classic partner for ipamorelin.
Learn more →Tesamorelin
GHRH analogue studied for visceral fat reduction.
Learn more →MK-677
Oral GH secretagogue — no injection required.
Learn more →Get ipamorelin in California
Physician consultation, prescription, and pharmacy delivery. No clinic visit required.
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Physician-reviewed