Growth Hormone Support
MK-677
The only GH secretagogue available in oral form — a once-daily capsule, no injections. MK-677 (ibutamoren) signals your own pituitary to release growth hormone for anti-aging, body composition, and sleep. Physician-prescribed for California patients.
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Physician-reviewed peptide therapy, prescribed only when appropriate.
Protocol at a glance
- Dose
- 10–25 mg
- Route
- Oral capsule
- Frequency
- Once daily
- Timing
- Before bed
- Course
- 3–6 months to assess
- Typical cost
- $100–200/mo
Physician-reviewed. Prescribed only if appropriate after a telehealth consult — full refund if a licensed clinician determines it isn't right for you.
Why patients choose it
Why patients choose MK-677
No needles
The only GH secretagogue available as an oral capsule — once-daily dosing with no injection site issues.
Sleep comes first
Improved sleep quality is usually the earliest benefit patients notice, often within 1–2 weeks of starting.
Stable, long-acting
A ~24-hour half-life produces a steady GH elevation from a single daily dose, rather than the short pulses of injectable GHRPs.
Overview
What MK-677 is
MK-677 (ibutamoren mesylate) is a non-peptide ghrelin receptor agonist that mimics the GH-releasing action of ghrelin. Unlike peptide-based GHRPs (ipamorelin, GHRP-2), MK-677 is orally bioavailable and has a half-life of approximately 24 hours — allowing once-daily oral dosing rather than daily injections.
It stimulates GH release via the same ghrelin receptor pathway as ipamorelin, with the primary practical advantages being oral administration and long duration of action. The primary trade-off compared to injectable GHRPs is slightly more pronounced appetite stimulation and water retention, particularly early in the protocol.
Candidacy
Who it's for
MK-677 is most commonly pursued by adults who want GH optimization without committing to a daily injection protocol — and who value the convenience of a single oral capsule. It suits patients prioritizing sleep, recovery, and gradual body composition changes.
California patients who ask about MK-677 typically describe some combination of:
- A preference for oral dosing over injections
- Poor or non-restorative sleep
- A desire for lean mass gain and fat reduction alongside consistent training
- Interest in GH support without the daily-injection burden of GHRPs
What to expect
How it unfolds, week by week
01
Weeks 1–2
Improved sleep quality is typically the first benefit noticed. Increased appetite is common in this early window, along with some water retention.
02
Weeks 4–8
IGF-1 levels typically increase measurably. Your physician may order labs in this window to confirm your response and calibrate dosing.
03
Months 3–6
Body composition changes — lean mass gain and fat reduction — develop with consistent use and adequate training.
MK-677 vs. injectable GHRPs
| MK-677 | Ipamorelin / GHRP-2 | |
|---|---|---|
| Administration | Oral capsule — no injections, no injection site issues. | Subcutaneous injection, typically daily. |
| Half-life | Long (~24 hours) — a single daily dose gives a stable GH elevation. | Short — produces a more pulsatile, physiologic GH release. |
| Trade-offs | More pronounced appetite stimulation and early water retention; can transiently raise blood glucose. | Less appetite stimulation, but requires a daily injection protocol. |
| Typical cost | $100–200/month | $200–350/month |
Safety
Side effects & considerations
MK-677 is generally well-tolerated. The most commonly reported effects:
- Increased appetite, especially in the first few weeks
- Water retention early in the protocol
- Transient blood sugar elevation and reduced insulin sensitivity
- A less pulsatile GH profile than injectable options
Because MK-677 can transiently raise blood glucose, it warrants caution in patients with pre-diabetes, type 2 diabetes, or insulin resistance. Your physician will assess your metabolic labs before prescribing.
Pricing
Cost in California
Compounded MK-677 runs $100–200/month, depending on dose. Consultation fees apply for the initial visit, and your physician may order labs to confirm your response. See our full cost guide.
FAQ
MK-677 questions
Related peptides
Often explored together
Ipamorelin
Injectable GH secretagogue acting on the same ghrelin receptor pathway.
Learn more →Sermorelin
GHRH analogue that prompts your own pituitary to make growth hormone.
Learn more →CJC-1295
Long-acting GHRH analogue; commonly stacked with ipamorelin.
Learn more →Tesamorelin
GHRH analogue studied for visceral fat reduction.
Learn more →Get MK-677 in California
Physician consultation, prescription, and oral capsules delivered to your door. No clinic visit required.
Check Your EligibilityMK-677
Physician-reviewed