Longevity
NAD+
The coenzyme that powers every cell in your body — and declines roughly 50% between ages 40 and 60. Injectable and IV NAD+ restore cellular energy, activate sirtuin longevity pathways, and support cognitive clarity. Physician-prescribed for California patients.
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Physician-reviewed peptide therapy, prescribed only when appropriate.
Protocol at a glance
- Dose
- 50–100 mg (injectable)
- Route
- Subcutaneous / IM injection or IV infusion
- Frequency
- 2–3x/week (injectable maintenance)
- Course
- Initial series, then monthly maintenance
- Typical cost
- $150–350/mo injectable
Physician-reviewed. Prescribed only if appropriate after a telehealth consult — full refund if a licensed clinician determines it isn't right for you.
Why patients choose it
Why patients choose NAD+
Cellular energy you can feel
NAD+ is the essential cofactor in mitochondrial ATP synthesis — many patients describe a marked lift in energy and reduced fatigue within hours of an infusion.
Mental clarity
By supporting neuronal health and reducing neuroinflammation, NAD+ is reported to sharpen cognitive function and clear brain fog.
Longevity at the source
NAD+ powers DNA repair via PARP enzymes and activates sirtuin longevity genes — the same pathways switched on by caloric restriction and exercise.
Overview
What NAD+ is
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It sits at the center of three processes that define how well a cell ages: energy production, DNA repair, and longevity signaling.
- Energy production: an essential cofactor in mitochondrial ATP synthesis — without NAD+, cells cannot produce energy efficiently.
- DNA repair: required by PARP enzymes that repair DNA strand breaks — critical for preventing cancer and aging.
- Sirtuin activation: sirtuins (SIRT1–7) are longevity genes activated by NAD+ — they regulate inflammation, metabolism, and cellular stress responses.
- Neuroprotection: supports neuronal health through SIRT1/3, reduces neuroinflammation, and supports mitochondrial function in brain tissue.
Candidacy
Who it's for
NAD+ therapy is most often pursued by adults navigating the steep mid-life decline in NAD+ — roughly 50% between ages 40 and 60 — and the fatigue, brain fog, and metabolic changes that track with it. It is also used in addiction medicine, where IV NAD+ has shown effectiveness in reducing withdrawal symptoms and cravings for opioids, alcohol, and stimulants.
California patients who ask about NAD+ typically describe some combination of:
- Persistent fatigue or low cellular energy
- Brain fog and reduced mental clarity
- An interest in longevity and DNA-repair / sirtuin pathways
- Recovery support for addiction or substance withdrawal
NAD+ delivery methods compared
| IV Infusion | Injectable (SQ/IM) | Oral (NMN/NR) | |
|---|---|---|---|
| Bioavailability | 100% | High | Variable |
| Speed of effect | Hours | Hours–days | Days–weeks |
| Convenience | Low (clinic) | High (home) | Highest |
| CA cost | $300–600/session | $150–350/mo | $50–150/mo |
Safety
Side effects & contraindications
NAD+ is a naturally occurring molecule in every human cell — not a foreign compound — and at therapeutic doses serious adverse events have not been reported. The main considerations:
- IV infusion can cause transient nausea, chest tightness, muscle cramps, and a feeling of pressure, particularly at higher infusion rates — slowing the drip minimizes them.
- Sessions are not dangerous, but the in-infusion sensations can be uncomfortable.
- Patients with cardiac arrhythmias should discuss IV protocols with their physician before starting.
Pricing
Cost in California
Injectable NAD+ for home use runs $150–350/month. IV sessions at clinics run $300–600 per infusion. Consultation fees are $99–199. See our full cost guide.
FAQ
NAD+ questions
Related peptides
Often explored together
MOTS-c
Mitochondrial-derived peptide for metabolism and cellular energy.
Learn more →Glutathione
Master antioxidant, often paired with NAD+ for cellular health.
Learn more →MK-677
Oral GH secretagogue used as a longevity-adjacent protocol.
Learn more →Tesamorelin
GHRH analogue studied for metabolic and body-composition changes.
Learn more →Get NAD+ in California
Physician consultation, prescription, and pharmacy delivery. No clinic visit required for injectable protocols.
Check Your EligibilityNAD+
Physician-reviewed