Growth Hormone Support
Sermorelin
Sleep, recovery, and body composition — from a peptide that prompts your own pituitary to make growth hormone, rather than injecting synthetic HGH. Physician-prescribed and pharmacy-compounded for California patients.
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Physician-reviewed peptide therapy, prescribed only when appropriate.
Protocol at a glance
- Dose
- 100–300 mcg
- Route
- Subcutaneous injection
- Frequency
- 5 days/week
- Timing
- Before bed
- Course
- 3–6 months to assess
- Typical cost
- $200–350/mo
Physician-reviewed. Prescribed only if appropriate after a telehealth consult — full refund if a licensed clinician determines it isn't right for you.
Why patients choose it
Why patients choose sermorelin
Works with your body
Stimulates your own pituitary to release GH instead of adding synthetic hormone, so your natural feedback loops stay intact.
Sleep comes first
Deeper, more restorative sleep is usually the earliest change — often within 2–4 weeks of starting.
Built for the long run
A favorable safety profile for sustained, physician-supervised use — and a fraction of the cost of pharmaceutical HGH.
Overview
What sermorelin is
Sermorelin is a synthetic analogue of growth hormone releasing hormone (GHRH), a peptide naturally produced in the hypothalamus. It consists of the first 29 amino acids of endogenous GHRH and retains full biological activity.
The key distinction from synthetic HGH: sermorelin doesn't add growth hormone to your bloodstream. It tells your pituitary gland to make more of its own. Your body's natural negative feedback mechanisms remain active, which prevents the oversaturation that can occur with direct HGH administration.
Candidacy
Who it's for
Sermorelin is most commonly pursued by adults in their 40s and 50s experiencing the gradual GH decline that happens with age — a process called somatopause. After 30, GH secretion drops roughly 14% per decade. By 60, it's often a fraction of peak levels.
California patients who ask about sermorelin typically describe some combination of:
- Poor sleep quality or non-restorative sleep
- Slower recovery from workouts compared to their 30s
- Gradual body composition changes (more fat, less muscle) despite consistent habits
- Low energy that doesn't improve with sleep or lifestyle changes
What to expect
How it unfolds, week by week
01
Weeks 2–4
Most patients notice improved sleep first — deeper sleep, more vivid dreams, and waking more rested as the pituitary responds.
02
Weeks 4–8
Energy improvements and reduced recovery time from exercise are reported in this window. Some patients notice modest skin-texture changes.
03
Months 3–6
Body composition shifts become measurable — reduced visceral fat, improved lean mass. IGF-1 is typically rechecked at 3 months to adjust dosing.
Sermorelin vs. Ipamorelin / CJC-1295
| Sermorelin | Ipamorelin / CJC-1295 | |
|---|---|---|
| Mechanism | GHRH analogue — signals the pituitary through the GHRH receptor. | Ipamorelin acts on the ghrelin receptor; CJC-1295 is a long-acting GHRH analogue. Combined, they amplify the GH pulse. |
| Half-life | Short — mimics the body's natural pulsatile GH release. | CJC-1295 is long-acting, producing a more sustained elevation. |
| Best for | Patients new to peptide therapy — simpler protocol, well-understood safety. | Patients escalating after they've already responded to sermorelin. |
| Typical cost | $200–350/month | $200–350/month (combination vial) |
Safety
Side effects & contraindications
Sermorelin is generally well-tolerated. The most commonly reported side effects:
- Injection site redness or mild swelling (usually resolves in minutes)
- Flushing, particularly when starting
- Headache in the first few weeks
- Hyperactivity in some patients — a sign the dose may be too high
Sermorelin is contraindicated in patients with active malignancy. If you have a history of cancer, disclose this to your physician before starting.
Pricing
Cost in California
Compounded sermorelin through a California-licensed pharmacy runs $200–350/month, depending on dose and concentration. Consultation fees are $99–199 for the initial visit, and lab work (IGF-1) runs $40–80. See our full cost guide.
FAQ
Sermorelin questions
Related peptides
Often explored together
Ipamorelin
A selective GH secretagogue, often the next step after sermorelin.
Learn more →CJC-1295
Long-acting GHRH analogue; commonly stacked with ipamorelin.
Learn more →Tesamorelin
GHRH analogue studied for visceral fat reduction.
Learn more →MK-677
Oral GH secretagogue — no injection required.
Learn more →Get sermorelin in California
Physician consultation, prescription, and pharmacy delivery. No clinic visit required.
Check Your EligibilitySermorelin
Physician-reviewed