Tissue Repair
TB-500
A synthetic fragment of thymosin beta-4 — a protein concentrated in wound fluid — used by athletes and active patients for injury recovery, soft tissue repair, and inflammation reduction. Physician oversight required for California patients.
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Physician-reviewed peptide therapy, prescribed only when appropriate.
Protocol at a glance
- Dose
- 2–2.5 mg
- Route
- Subcutaneous or intramuscular injection
- Frequency
- Twice weekly (loading)
- Course
- 4–6 week loading phase
- Typical cost
- $80–150/vial
Physician-reviewed. Prescribed only if appropriate after a telehealth consult — full refund if a licensed clinician determines it isn't right for you.
Why patients choose it
Why patients choose TB-500
Built for soft tissue
Strongest for muscle and broad soft tissue repair — tendinopathies, strains, and ligament injuries that haven't responded to PT alone.
Broad anti-inflammatory action
Downregulates pro-inflammatory cytokines and promotes new blood vessel formation, improving circulation to injured tissue.
Stacks with BPC-157
Different mechanism than BPC-157, so the two are commonly combined in athletic recovery protocols for broader coverage.
Overview
What TB-500 is
Thymosin Beta-4 is a 43-amino-acid protein that occurs naturally in most human tissue. It's found in particularly high concentrations in wound fluid and platelets — places where tissue repair is actively occurring. TB-500 is a synthetic fragment of this protein, derived from the actin-binding region (the sequence LKKTETQ), which appears to be responsible for the bulk of its biological activity.
It is not FDA-approved for any indication. Available in California from licensed compounding pharmacies with physician oversight. The research base is primarily preclinical — animal studies and in vitro work — with some early human trial data on the full thymosin beta-4 protein in cardiac injury contexts.
TB-500's effects appear to work through several overlapping pathways:
- Actin sequestration: binds G-actin and regulates actin polymerization, which is critical for cell migration and wound healing
- Angiogenesis: promotes formation of new blood vessels, improving circulation to injured tissue
- Anti-inflammatory: downregulates several pro-inflammatory cytokines at injury sites
- Stem cell recruitment: preclinical data suggests TB-4 mobilizes stem cells from bone marrow to areas of injury
Most mechanism data comes from animal models. Human clinical evidence is limited. For educational purposes only — consult your physician for treatment decisions.
Candidacy
Who it's for
California patients pursuing TB-500 are almost always dealing with a specific injury. This is not a general wellness peptide like sermorelin. Common profiles:
- Runners with chronic Achilles or patellar tendinopathy
- CrossFit athletes with rotator cuff issues or elbow tendinitis
- Post-surgical patients who want to accelerate healing after orthopedic procedures
- Active adults in their 40s–60s with soft tissue injuries that have not responded to physical therapy alone
- Patients who have used BPC-157 and want a complementary compound for broader tissue repair
What to expect
How it unfolds, week by week
01
Weeks 1–2
Loading phase begins at 2–2.5mg twice weekly. Acute injuries may respond faster — some patients report meaningful improvement within 2–3 weeks of starting.
02
Weeks 4–6
The standard loading phase completes. Chronic injuries present for months or years tend to require this full window before measurable improvement.
03
After loading
Most patients transition to a maintenance dose of 2–2.5mg once weekly, or cycle off and assess with their physician.
TB-500 vs. BPC-157
| TB-500 | BPC-157 | |
|---|---|---|
| Primary strength | Muscle & broad soft tissue | Tendon-to-bone & gut |
| Anti-inflammatory | Strong systemic effect | Localized to injury site |
| Admin route | Injection only | Injection or oral capsule |
| Typical cost | $80–150/vial | $150–250/month |
Safety
Side effects & contraindications
Human safety data on TB-500 specifically is limited. Based on preclinical studies and clinical use experience, it appears well-tolerated at standard doses. Reported side effects are uncommon and typically mild:
- Injection site reactions (redness, mild swelling)
- Transient fatigue or lethargy following injection
- Head rush or lightheadedness in some patients
Due to its angiogenic and cell-proliferative effects, TB-500 is not recommended for patients with a history of cancer or active malignancy. Disclose your full medical history to your prescribing physician.
Pricing
Cost in California
TB-500 from a California-licensed compounding pharmacy runs $80–150 per vial. A standard loading protocol (4–6 weeks at twice-weekly dosing) requires 8–12 vials. Consultation fees are $99–199. See our full cost guide.
FAQ
TB-500 questions
Related peptides
Often explored together
BPC-157
Tendon-to-bone and gut healing peptide; commonly stacked with TB-500.
Learn more →GHK-Cu
Copper peptide studied for skin, wound healing, and tissue remodeling.
Learn more →Thymosin Alpha-1
Thymic peptide used for immune modulation and recovery.
Learn more →Sermorelin
GHRH analogue for sleep, recovery, and body composition.
Learn more →Get TB-500 in California
Physician consultation, prescription, and pharmacy delivery. No clinic visit required.
Check Your EligibilityTB-500
Physician-reviewed